Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

J Cutan Med Surg. 2016 May;20(3):207-10. doi: 10.1177/1203475415622207. Epub 2015 Dec 9.


Background: Vitamin D has been shown to have immunomodulatory effects, and previous studies have proposed a role of vitamin D deficiency in multiple autoimmune diseases, including psoriasis.

Objectives: The aim of this study was to investigate serum vitamin D levels in psoriatic patients and compare them with levels in controls.

Methods: This study was carried out in 50 psoriasis patients. Serum vitamin D was measured by enzyme-linked immunosorbent assay.

Results: The mean serum vitamin D levels in psoriatic patients and controls were 14.92 ± 6.31 and 12.52 ± 4.54 ng/mL, respectively. The difference was not statistically significant (P = .06). The prevalence of vitamin D deficiency (<20 ng/mL) was 84.0% in psoriatic patients and 93.0% in controls (P = .21).

Conclusions: Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.

Keywords: Psoriasis Area and Severity Index (PASI); psoriasis; serum vitamin D.

MeSH terms

  • Adult
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Iran
  • Male
  • Middle Aged
  • Psoriasis / blood*
  • Psoriasis / complications
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood*
  • Vitamin D Deficiency / complications


  • Vitamin D
  • 25-hydroxyvitamin D