Cost-effectiveness of a European ST-segment elevation myocardial infarction network: results from the Catalan Codi Infart network

BMJ Open. 2015 Dec 9;5(12):e009148. doi: 10.1136/bmjopen-2015-009148.

Abstract

Objectives: To evaluate the cost-effectiveness of the ST-segment elevation myocardial infarction (STEMI) network of Catalonia (Codi Infart).

Design: Cost-utility analysis.

Setting: The analysis was from the Catalonian Autonomous Community in Spain, with a population of about 7.5 million people.

Participants: Patients with STEMI treated within the autonomous community of Catalonia (Spain) included in the IAM CAT II-IV and Codi Infart registries.

Outcome measures: Costs included hospitalisation, procedures and additional personnel and were obtained according to the reperfusion strategy. Clinical outcomes were defined as 30-day avoided mortality and quality-adjusted life-years (QALYs), before (N=356) and after network implementation (N=2140).

Results: A substitution effect and a technology effect were observed; aggregate costs increased by 2.6%. The substitution effect resulted from increased use of primary coronary angioplasty, a relatively expensive procedure and a decrease in fibrinolysis. Primary coronary angioplasty increased from 31% to 89% with the network, and fibrinolysis decreased from 37% to 3%. Rescue coronary angioplasty declined from 11% to 4%, and no reperfusion from 21% to 4%. The technological effect was related to improvements in the percutaneous coronary intervention procedure that increased efficiency, reducing the average length of the hospital stay. Mean costs per patient decreased from €8306 to €7874 for patients with primary coronary angioplasty. Clinical outcomes in patients treated with primary coronary angioplasty did not change significantly, although 30-day mortality decreased from 7.5% to 5.6%. The incremental cost-effectiveness ratio resulted in an extra cost of €4355 per life saved (30-day mortality) and €495 per QALY. Below a cost threshold of €30,000, results were sensitive to variations in costs and outcomes.

Conclusions: The Catalan STEMI network (Codi Infart) is cost-efficient. Further studies are needed in geopolitical different scenarios.

Keywords: HEALTH ECONOMICS.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary
  • Cost-Benefit Analysis
  • Female
  • Humans
  • Length of Stay / economics*
  • Male
  • Middle Aged
  • Myocardial Infarction / economics*
  • Myocardial Infarction / mortality*
  • Myocardial Infarction / therapy*
  • Percutaneous Coronary Intervention / economics*
  • Quality-Adjusted Life Years
  • Registries
  • Spain