Applications of CRISPR-Cas systems in neuroscience

Nat Rev Neurosci. 2016 Jan;17(1):36-44. doi: 10.1038/nrn.2015.2. Epub 2015 Dec 10.


Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal models and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CRISPR-Cas Systems / physiology*
  • Clustered Regularly Interspaced Short Palindromic Repeats / physiology*
  • Genetic Engineering*
  • Humans
  • Neurosciences*
  • Translational Research, Biomedical*