Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Nat Neurosci. 2016 Jan;19(1):37-9. doi: 10.1038/nn.4192. Epub 2015 Dec 14.


To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Clozapine / analogs & derivatives
  • Designer Drugs
  • Female
  • Genetic Techniques
  • Genetic Vectors
  • Lentivirus
  • Macaca mulatta
  • Male
  • Mental Recall / physiology*
  • Mice
  • Parahippocampal Gyrus / physiology*
  • Prefrontal Cortex / physiology*
  • Reward*
  • Temporal Lobe / physiology*


  • Designer Drugs
  • Clozapine
  • clozapine N-oxide