Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation

J Virol. 2015 Dec 9;90(4):2150-4. doi: 10.1128/JVI.02456-15. Print 2016 Feb 15.


Interleukin 6 (IL-6) is considered a proliferation and survival factor for B cells. To assess the role of IL-6 in Kaposi sarcoma-associated herpesvirus (KSHV) latency, KSHV latency locus-transgenic mice (referred to as latency mice) lacking IL-6 were evaluated. IL-6(-/-) latency mice had the same phenotypes as the latency mice, i.e., increased frequency of marginal zone B cells, hyperplasia, and hyperglobulinemia, indicating that the KSHV latency locus, which includes all viral microRNAs (miRNAs), can compensate for lack of IL-6 in premalignant B cell activation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • B-Lymphocytes / virology*
  • Herpesvirus 8, Human / physiology*
  • Interleukin-6 / deficiency
  • Interleukin-6 / metabolism*
  • Lymphocyte Activation*
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Virus Latency*


  • Interleukin-6