Dynorphin, Dysphoria, and Dependence: the Stress of Addiction

Neuropsychopharmacology. 2016 Jan;41(1):373-4. doi: 10.1038/npp.2015.258.

Authors

Charles Chavkin¹, George F Koob²

Affiliations

¹ Department of Pharmacology, University of Washington, Seattle, WA, USA.
² National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Behavior, Addictive / metabolism*
Behavior, Addictive / psychology
Behavior, Addictive / therapy
Benzamides / pharmacology
Benzamides / therapeutic use
Depressive Disorder, Major / metabolism*
Depressive Disorder, Major / psychology
Depressive Disorder, Major / therapy
Dynorphins / metabolism*
Humans
Pyrrolidines / pharmacology
Pyrrolidines / therapeutic use
Receptors, Opioid, kappa / antagonists & inhibitors
Receptors, Opioid, kappa / metabolism
Stress, Psychological / metabolism*
Stress, Psychological / psychology
Stress, Psychological / therapy

Substances

Benzamides
Pyrrolidines
Receptors, Opioid, kappa
Dynorphins
Aticaprant