ECM and ECM-like materials - Biomaterials for applications in regenerative medicine and cancer therapy

Svenja Hinderer; Shannon Lee Layland; Katja Schenke-Layland

doi:10.1016/j.addr.2015.11.019

ECM and ECM-like materials - Biomaterials for applications in regenerative medicine and cancer therapy

Adv Drug Deliv Rev. 2016 Feb 1:97:260-9. doi: 10.1016/j.addr.2015.11.019. Epub 2015 Dec 3.

Authors

Svenja Hinderer¹, Shannon Lee Layland¹, Katja Schenke-Layland²

Affiliations

¹ Department of Women's Health, Research Institute for Women's Health, Eberhard Karls University, Silcherstrasse 7/1, 72076 Tübingen, Germany; Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, 70569 Stuttgart, Germany.
² Department of Women's Health, Research Institute for Women's Health, Eberhard Karls University, Silcherstrasse 7/1, 72076 Tübingen, Germany; Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, 70569 Stuttgart, Germany; Department of Medicine/Cardiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, 675 Charles E. Young Drive South, MRL 3645, Los Angeles, CA, United States. Electronic address: katja.schenke-layland@med.uni-tuebingen.de.

PMID: 26658243
DOI: 10.1016/j.addr.2015.11.019

Abstract

Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate or support damaged tissues and organs. In addition to careful cell type selection, the design of appropriate three-dimensional (3D) scaffolds is essential for the generation of bio-inspired replacement tissues. Such scaffolds are usually made of degradable or non-degradable biomaterials and can serve as cell or drug carriers. The development of more effective and efficient drug carrier systems is also highly relevant for novel cancer treatment strategies. In this review, we provide a summary of current approaches that employ ECM and ECM-like materials, or ECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine. We further discuss the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy.

Keywords: Cancer therapy; ECM; ECM-like; ECM-mimics; Electrospun release systems; Proteins; biomaterials.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials*
Drug Delivery Systems
Extracellular Matrix*
Humans
Neoplasms / therapy
Regenerative Medicine
Tissue Engineering

Substances

Biocompatible Materials