Long-term Safety and Efficacy of Mexiletine for Patients With Skeletal Muscle Channelopathies

JAMA Neurol. 2015 Dec;72(12):1531-3. doi: 10.1001/jamaneurol.2015.2338.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Channelopathies / drug therapy*
  • Channelopathies / genetics
  • Channelopathies / pathology*
  • Chloride Channels / genetics
  • Dose-Response Relationship, Drug
  • Electrocardiography
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Mexiletine / therapeutic use*
  • Muscle, Skeletal / pathology*
  • Mutation / genetics
  • NAV1.4 Voltage-Gated Sodium Channel / genetics
  • Randomized Controlled Trials as Topic
  • Voltage-Gated Sodium Channel Blockers / therapeutic use*

Substances

  • CLC-1 channel
  • Chloride Channels
  • NAV1.4 Voltage-Gated Sodium Channel
  • SCN4A protein, human
  • Voltage-Gated Sodium Channel Blockers
  • Mexiletine