Improving therapeutic effectiveness and safety through big healthcare data

Clin Pharmacol Ther. 2016 Mar;99(3):262-5. doi: 10.1002/cpt.316. Epub 2016 Jan 17.


Big healthcare data-electronically recorded longitudinal data generated during the provision and administration of healthcare for millions of patients-have become essential for understanding the effectiveness and safety of therapeutics. They are most effectively used in concert with experimental and laboratory research throughout the life cycle of a drug. Applications range from providing phenotype and health outcomes information in genome-wide association studies to postmarketing studies that assure prescribers of the safety of approved drugs (Figure ). [Figure: see text].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Factual*
  • Delivery of Health Care / statistics & numerical data*
  • Humans
  • Product Surveillance, Postmarketing*
  • Treatment Outcome*