Wegener's granulomatosis presenting as acute respiratory failure with anti-neutrophil-cytoplasm antibodies

Chest. 1989 Aug;96(2):345-7. doi: 10.1378/chest.96.2.345.


Anti-neutrophil-cytoplasm antibodies recently have been reported as serologic markers of Wegener's granulomatosis. We describe two cases in which this test appeared to be of great value in the diagnosis of Wegener's granulomatosis presenting as acute respiratory failure, a clinical setting in which it may be the only diagnostic test that can be safely and easily performed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoantibodies / analysis*
  • Biopsy
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fluorescent Antibody Technique
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Lung / pathology
  • Male
  • Neutrophils / immunology*
  • Respiratory Insufficiency / etiology*


  • Autoantibodies