Is sebocyte-derived leptin the missing link between hyperseborrhea, ductal hypoxia, inflammation and comedogenesis in acne vulgaris?

Exp Dermatol. 2016 Mar;25(3):181-2. doi: 10.1111/exd.12917. Epub 2016 Feb 10.

Author

Bodo C Melnik¹

Affiliation

¹ Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.

PMID: 26660941
DOI: 10.1111/exd.12917

No abstract available

Keywords: acne; inflammasome; leptin; mTORC1; western diet.

MeSH terms

Acne Vulgaris / physiopathology*
Animals
Cell Proliferation
Dermatitis, Seborrheic / physiopathology*
Humans
Hypoxia / physiopathology*
Inflammation / physiopathology*
Keratinocytes / cytology
Leptin / physiology*
Mechanistic Target of Rapamycin Complex 1
Mice
Multiprotein Complexes / metabolism
Sebaceous Glands / cytology*
TOR Serine-Threonine Kinases / metabolism

Substances

Leptin
Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases