Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

J Cereb Blood Flow Metab. 2016 Mar;36(3):576-80. doi: 10.1177/0271678X15620434. Epub 2015 Dec 7.


Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilation was evaluated on T2 images and related to cerebral amyloid angiopathy severity in overlying cortical areas on 34 tissue sections stained for Amyloid β. Degree of perivascular spaces dilation was significantly associated with cerebral amyloid angiopathy severity (odds ratio = 3.3, 95% confidence interval 1.3-7.9, p = 0.011). Thus, dilated juxtacortical perivascular spaces are a promising neuroimaging marker of cerebral amyloid angiopathy severity.

Keywords: 7 T magnetic resonance imaging; amyloid angiopathy; histology; microbleeds; perivascular spaces.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides / analysis*
  • Cerebral Amyloid Angiopathy / pathology*
  • Cerebral Cortex / blood supply*
  • Cerebral Cortex / pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male


  • Amyloid beta-Peptides