Novel Functions of Renin Precursors in Homeostasis and Disease

Physiology (Bethesda). 2016 Jan;31(1):25-33. doi: 10.1152/physiol.00039.2015.


Renin progenitors appear early and are found in multiple tissues throughout the embryo. Besides their well known role in blood pressure and fluid homeostasis, renin progenitors participate in tissue morphogenesis, repair, and regeneration, and may integrate immune and endocrine responses. In the bone marrow, renin cells offer clues to understand normal and neoplastic hematopoiesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology
  • Bone Marrow / metabolism
  • Bone Marrow / physiology
  • Hematopoiesis / physiology
  • Homeostasis / physiology*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / physiopathology
  • Renin / metabolism*
  • Renin-Angiotensin System / physiology*


  • Renin