Impact of surgical margin clearance for resection of secondary hepatic malignancies

J Surg Oncol. 2016 Mar;113(3):289-95. doi: 10.1002/jso.24107. Epub 2015 Dec 10.

Abstract

Over the past several decades, there has been increasing discussion regarding the optimal management of secondary liver malignancies. Traditionally, resection has only been recommended if it could be accomplished with negative microscopic margins of at least 10 mm. However, many investigators have pushed this limit to offer resection to patients with narrower margins. We review the data regarding the impact of margin clearance on outcomes for patients undergoing hepatic metastasectomy.

Keywords: colorectal liver metastases; frozen section analysis; non-colorectal liver metastases; resection margin; secondary liver malignancy.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms / pathology
  • Frozen Sections
  • Hepatectomy / standards*
  • Humans
  • Intraoperative Period
  • Liver Neoplasms / mortality
  • Liver Neoplasms / prevention & control
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery*
  • Neoplasm Recurrence, Local / prevention & control*
  • Neoplasm, Residual / prevention & control
  • Neuroendocrine Tumors / secondary
  • Neuroendocrine Tumors / surgery
  • Survival Rate
  • Treatment Outcome