Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):858-60. doi: 10.1002/anie.201510402. Epub 2015 Dec 11.

Authors

Jana Kundert¹, Tobias A M Gulder²

Affiliations

¹ Biosystems Chemistry, Center for Integrated Protein Science Munich (CIPSM) at the, Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748, Garching, Germany.
² Biosystems Chemistry, Center for Integrated Protein Science Munich (CIPSM) at the, Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748, Garching, Germany. tobias.gulder@ch.tum.de.

PMID: 26663672
DOI: 10.1002/anie.201510402

No abstract available

Keywords: crotonyl-CoA carboxylase/reductases; enzymes; metabolic engineering; polyketide biosynthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carboxy-Lyases / chemistry*
Oxidoreductases / chemistry*
Polyketide Synthases / chemistry*
Protein Conformation

Substances

Polyketide Synthases
Oxidoreductases
Carboxy-Lyases