Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum

J Bioenerg Biomembr. 1989 Apr;21(2):283-94. doi: 10.1007/BF00812073.


Rapid Ca2+ release from the sarcoplasmic reticulum (SR)3 can be triggered by either binding of heavy metals to a sulfhydryl (SH) group or by catalyzing the oxidation of endogenous groups to a disulfide. Ca2+ release has been monitored directly using isolated vesicle preparations or indirectly by monitoring phasic contractions in a skinned fiber preparation. SH oxidation triggered by addition of Cu2+/mercaptans, phthalocyanine dyes, reactive disulfides, and various anthraquinones appears to involve a direct interaction with the Ca2+ release protein from the SR. A model is presented in which reversible oxidation and reduction of endogenous SH groups results in the opening and closing of the Ca2+ release channel from the SR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Models, Theoretical
  • Muscles / physiology
  • Organelles / physiology
  • Sarcoplasmic Reticulum / physiology*
  • Sulfhydryl Compounds / metabolism


  • Sulfhydryl Compounds
  • Calcium