Neurological Effects of Bisphenol A and its Analogues

Int J Med Sci. 2015 Oct 30;12(12):926-36. doi: 10.7150/ijms.13267. eCollection 2015.


The endocrine disrupting chemical bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. The use of BPA-containing products in daily life makes exposure ubiquitous, and the potential human health risks of this chemical are a major public health concern. Although numerous in vitro and in vivo studies have been published on the effects of BPA on biological systems, there is controversy as to whether ordinary levels of exposure can have adverse effects in humans. However, the increasing incidence of developmental disorders is of concern, and accumulating evidence indicates that BPA has detrimental effects on neurological development. Other bisphenol analogues, used as substitutes for BPA, are also suspected of having a broad range of biological actions. The objective of this review is to summarize our current understanding of the neurobiological effects of BPA and its analogues, and to discuss preventive strategies from a public health perspective.

Keywords: Bisphenol A; Epigenetics; Neurodevelopment.

Publication types

  • Review

MeSH terms

  • Animals
  • Benzhydryl Compounds / toxicity*
  • Benzhydryl Compounds / urine
  • Environmental Exposure / analysis
  • Environmental Monitoring
  • Female
  • Hazardous Substances / toxicity
  • Hazardous Substances / urine
  • Humans
  • Male
  • Nervous System / drug effects*
  • Nervous System / growth & development*
  • Neurodevelopmental Disorders / chemically induced
  • Phenols / toxicity*
  • Phenols / urine
  • Public Health


  • Benzhydryl Compounds
  • Hazardous Substances
  • Phenols
  • bisphenol A