Unique features of long non-coding RNA biogenesis and function

Nat Rev Genet. 2016 Jan;17(1):47-62. doi: 10.1038/nrg.2015.10.


Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous biological processes across every branch of life. Although initially discovered as mRNA-like transcripts that do not encode proteins, recent studies have revealed features of lncRNAs that further distinguish them from mRNAs. In this Review, we describe special events in the lifetimes of lncRNAs - before, during and after transcription - and discuss how these events ultimately shape the unique characteristics and functional roles of lncRNAs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin / genetics
  • Chromatin / metabolism
  • Gene Expression
  • Gene Expression Regulation
  • Genomic Imprinting
  • Humans
  • RNA Processing, Post-Transcriptional
  • RNA Stability
  • RNA Transport
  • RNA, Long Noncoding / biosynthesis*
  • RNA, Long Noncoding / genetics


  • Chromatin
  • RNA, Long Noncoding