Acute Lung Injury Accompanying Alveolar Hemorrhage Associated with Flu Vaccination in the Elderly

Intern Med. 2015;54(24):3193-6. doi: 10.2169/internalmedicine.54.4894. Epub 2015 Dec 15.


Flu vaccinations are administered worldwide every winter for prevention. We herein describe a case of acute lung injury resulting from a pathologically confirmed alveolar hemorrhage, which may have been closely related to a preceding vaccination for pandemic influenza A of 2009/10. The present patient had been hospitalized with an acute lung injury after flu vaccination one year prior to the present hospitalization, however, he received another flu vaccination. We should consider a vaccine-related adverse reaction as a potential cause of pulmonary disease if patients present with this illness during the winter season.

Publication types

  • Case Reports

MeSH terms

  • Acute Lung Injury / etiology*
  • Aged, 80 and over
  • Hemorrhage / chemically induced*
  • Hemorrhage / complications*
  • Humans
  • Influenza Vaccines / adverse effects*
  • Influenza, Human / epidemiology
  • Lung Diseases / chemically induced*
  • Lung Diseases / complications*
  • Male
  • Seasons


  • Influenza Vaccines