Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring

J Endocrinol Invest. 2016 Jun;39(6):643-55. doi: 10.1007/s40618-015-0413-5. Epub 2015 Dec 14.

Abstract

The effect of in-utero environment on fetal health and survival is long-lasting, and this is known as the fetal origin hypothesis. The oxidative stress state during gestation could play a pivotal role in fetal programming and development of diseases such as diabetes. In this study, we investigated the effect of intra-uterine obesity and malnutrition on oxidative stress markers in pancreatic and peripheral tissues of F1 offspring both prenatally and postnatally. Furthermore, the effect of postnatal diet on oxidative stress profile was evaluated. The results indicated that intra-uterine obesity and malnourishment significantly increased oxidative stress in F1 offspring. Moreover, the programming effect of obesity was more pronounced and protracted than malnutrition. The obesity-induced programming of offspring tissues was independent of high-caloric environment that the offspring endured; however, high-caloric diet potentiated its effect. In addition, pancreas and liver were the most affected tissues by fetal reprogramming both prenatally and postnatally. In conclusion, maternal obesity and malnutrition-induced oxidative stress could predispose offspring to insulin resistance and diabetes.

Keywords: Apoptosis; Fetal origin of disease; Fetal programming; Malnutrition; Obesity; Oxidative stress.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / etiology
  • Diabetes Mellitus, Experimental / physiopathology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fetal Development
  • Lipid Peroxidation
  • Malnutrition / complications*
  • Obesity / complications*
  • Oxidative Stress*
  • Perinatal Care*
  • Pregnancy
  • Pregnancy Outcome
  • Prenatal Exposure Delayed Effects / etiology
  • Prenatal Exposure Delayed Effects / physiopathology*
  • Rats
  • Rats, Wistar