Original footage of the Chilean miners with manganism published in Neurology in 1967

Neurology. 2015 Dec 15;85(24):2166-9. doi: 10.1212/WNL.0000000000002223.


Manganism has captured the imagination of neurologists for more than a century because of its similarities to Parkinson disease and its indirect but seminal role in the "l-dopa miracle." We present unpublished footage of the original case series reported in Neurology® in 1967 by Mena and Cotzias depicting the typical neurologic signs of manganism in 4 Chilean miners and their response to high doses of l-dopa.

Publication types

  • Historical Article

MeSH terms

  • Chile
  • History, 20th Century
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Manganese Poisoning / diagnosis
  • Manganese Poisoning / drug therapy
  • Manganese Poisoning / history*
  • Miners / history*
  • Neurology / history*
  • Occupational Exposure / history*


  • Levodopa