Association of Class I Major Histocompatibility Heavy and Light Chains Induced by Viral Peptides

Nature. 1989 Aug 10;340(6233):443-8. doi: 10.1038/340443a0.

Abstract

We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Membrane / immunology
  • Cell Transformation, Viral
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class I / isolation & purification
  • Macromolecular Substances
  • Mutation
  • Nucleoproteins / immunology
  • Orthomyxoviridae / genetics
  • Protein Conformation
  • RNA-Binding Proteins*
  • Viral Core Proteins*
  • Viral Proteins / immunology
  • beta 2-Microglobulin / immunology
  • beta 2-Microglobulin / isolation & purification

Substances

  • Histocompatibility Antigens Class I
  • Macromolecular Substances
  • NP protein, Influenza A virus
  • Nucleoproteins
  • RNA-Binding Proteins
  • Viral Core Proteins
  • Viral Proteins
  • beta 2-Microglobulin