GPR55 - a putative "type 3" cannabinoid receptor in inflammation

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):297-302. doi: 10.1515/jbcpp-2015-0080.

Abstract

G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classical cannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes a different signaling system and downstream cascade associated with the receptor. Therefore, GPR55 has emerged as a putative "type 3" cannabinoid receptor, establishing a novel class of cannabinoid receptor. Furthermore, the recent evidence of GPR55-CB1 and GPR55-CB2 heteromerization along with its broad distribution from central nervous system to peripheries suggests the importance of GPR55 in various cellular processes and pathologies and as a potential therapeutic target in inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Cannabinoids / metabolism
  • Humans
  • Inflammation / metabolism*
  • Receptors, Cannabinoid / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction / physiology

Substances

  • Cannabinoids
  • Receptors, Cannabinoid
  • Receptors, G-Protein-Coupled