Cognitive evaluation by tasks in a virtual reality environment in multiple sclerosis

J Neurol Sci. 2015 Dec 15;359(1-2):94-9. doi: 10.1016/j.jns.2015.10.039. Epub 2015 Oct 23.


Background: The assessment of cognitive impairment in multiple sclerosis (MS) requires large neuropsychological batteries that assess numerous domains. The relevance of these assessments to daily cognitive functioning is not well established. Cognitive ecological evaluation has not been frequently studied in MS.

Objectives: The aim of this study was to determine the interest of cognitive evaluation in a virtual reality environment in a sample of persons with MS with cognitive deficits.

Methods: Thirty persons with MS with at least moderate cognitive impairment were assessed with two ecological evaluations, an in-house developed task in a virtual reality environment (Urban DailyCog®) and a divided attention task in a driving simulator. Classical neuropsychological testing was also used.

Results and conclusion: Fifty-two percent of the persons with MS failed the driving simulator task and 80% failed the Urban DailyCog®. Virtual reality assessments are promising in identifying cognitive impairment in MS.

Keywords: Cognition; Cognitive assessment; Ecological evaluation; Multiple sclerosis; Neuropsychology; Virtual reality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / etiology*
  • Cognition Disorders / genetics*
  • Computer Simulation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications*
  • Multiple Sclerosis / rehabilitation
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Statistics as Topic
  • User-Computer Interface*