Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

Science. 1989 Jul 28;245(4916):371-8. doi: 10.1126/science.2667136.

Abstract

The cloning of genes encoding mammalian DNA binding transcription factors for RNA polymerase II has provided the opportunity to analyze the structure and function of these proteins. This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors. The mechanisms by which these factors may activate transcriptional initiation and by which they may be regulated to achieve differential gene expression are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation
  • Molecular Sequence Data
  • Protein Processing, Post-Translational
  • RNA Polymerase II / genetics*
  • RNA Polymerase II / metabolism
  • Repetitive Sequences, Nucleic Acid
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Transcription Factors
  • RNA Polymerase II