Early detection of genital chlamydial infection in women: an economic evaluation

Sex Transm Dis. Jan-Mar 1989;16(1):21-7. doi: 10.1097/00007435-198901000-00005.


A decision analysis model was constructed for comparison of early detection of asymptomatic genital chlamydial infection in women by the direct immunofluorescence antibody (DFA) test and the enzyme-linked immunosorbent assay (ELISA) with no intervention. Early-detection programs using the DFA test and ELISA were shown to be cost-effective in female populations where the prevalences of chlamydial infection exceeded 6% and 7%, respectively. Sensitivity analysis showed that the two most important factors were the probability of developing pelvic inflammatory disease and the cost of the test. The DFA method was more appropriate for an early-detection program because of its higher sensitivity.

MeSH terms

  • Chlamydia Infections / diagnosis*
  • Chlamydia Infections / economics
  • Chlamydia trachomatis / isolation & purification
  • Costs and Cost Analysis
  • Decision Support Techniques
  • Decision Trees
  • Diagnostic Services / economics*
  • Enzyme-Linked Immunosorbent Assay / economics
  • Enzyme-Linked Immunosorbent Assay / standards
  • Female
  • Fluorescent Antibody Technique / economics
  • Fluorescent Antibody Technique / standards
  • Genital Diseases, Female / diagnosis*
  • Genital Diseases, Female / economics
  • Humans
  • Models, Statistical