The great GATC: DNA methylation in E. coli

Trends Genet. 1989 May;5(5):139-43. doi: 10.1016/0168-9525(89)90054-1.


In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Base Sequence
  • Chromosomes, Bacterial
  • DNA Modification Methylases / metabolism*
  • DNA Replication
  • DNA, Bacterial / genetics
  • DNA, Bacterial / metabolism*
  • Escherichia coli / genetics*
  • Gene Expression Regulation
  • Methylation


  • DNA, Bacterial
  • DNA Modification Methylases