Signalling to the nucleus under the control of light and small molecules

Mol Biosyst. 2016 Feb;12(2):345-9. doi: 10.1039/c5mb00763a.


One major regulatory mechanism in cell signalling is the spatio-temporal control of the localization of signalling molecules. We synthetically designed an entire cell signalling pathway, which allows controlling the transport of signalling molecules from the plasma membrane to the nucleus, by using light and small molecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus
  • Amino Acid Sequence
  • Arabidopsis Proteins / physiology*
  • Basic Helix-Loop-Helix Transcription Factors / physiology
  • Cell Nucleus / metabolism*
  • Endopeptidases / physiology
  • Green Fluorescent Proteins / biosynthesis
  • Green Fluorescent Proteins / genetics
  • HeLa Cells
  • Humans
  • Metabolic Engineering
  • Phytochrome B / physiology*
  • Signal Transduction / radiation effects*
  • Transfection


  • Arabidopsis Proteins
  • Basic Helix-Loop-Helix Transcription Factors
  • PHYB protein, Arabidopsis
  • PIF3 protein, Arabidopsis
  • enhanced green fluorescent protein
  • Phytochrome B
  • Green Fluorescent Proteins
  • Endopeptidases
  • TEV protease