Assessing the role of TUBA4A gene in frontotemporal degeneration

Neurobiol Aging. 2016 Feb;38:215.e13-215.e14. doi: 10.1016/j.neurobiolaging.2015.10.030. Epub 2015 Nov 5.

Abstract

The tubulin alpha 4a (TUBA4A) gene has been recently associated with amyotrophic lateral sclerosis. Interestingly, some of the mutation carriers were also diagnosed with frontotemporal degeneration (FTD) or mild cognitive impairment. With the aim to investigate the role of TUBA4A in FTD, we screened TUBA4A in a series of 814 FTD patients from Spain. Our data did not disclose any nonsense or missense variant in the cohort, thus suggesting that TUBA4A mutations are not associated with FTD.

Keywords: Amyotrophic lateral sclerosis; Frontotemporal degeneration; Genetics; TUBA4A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / genetics
  • Cohort Studies
  • Female
  • Frontotemporal Dementia / genetics*
  • Genetic Association Studies*
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Mutation*
  • Tubulin / genetics*

Substances

  • Tubulin