3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Adv Healthc Mater. 2016 Feb 4;5(3):335-41. doi: 10.1002/adhm.201500740. Epub 2015 Dec 16.


3D micropillars generated by photolithography are used as a platform to probe by atomic force microscopy the mechanodynamics of human induced pluripotent stem cell-derived cardiomyocytes. 3D micropillars guide subcellular cytoskeletal modifications of cardiomyocytes and lead to biochemical changes altering beating rate, stiffness, and calcium dynamics of the cells.

Keywords: 3D micropillars; atomic force microscopy; induced pluripotent stem cells; mechanobiology; sarcomeres.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism
  • Cell Differentiation / physiology
  • Cells, Cultured
  • Humans
  • Induced Pluripotent Stem Cells / metabolism
  • Induced Pluripotent Stem Cells / physiology*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / physiology*


  • Calcium