Sinonasal mucosal melanoma: A 12-year experience of 58 cases

Head Neck. 2016 Apr:38 Suppl 1:E1737-45. doi: 10.1002/hed.24309. Epub 2015 Dec 17.


Background: Sinonasal mucosal melanoma is a rare malignancy with poor prognosis.

Methods: Patients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event-free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model.

Results: Pathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS was 43.5% and 29% and event-free survival was 23.6% and 12.4%, respectively. At univariate analysis, OS was significantly influenced by male sex, advanced pT classification, positive margins, and surgical approach; event-free survival was affected by positive margins. At multivariate analysis, the risk of death was independently associated with male sex (hazard ratio [HR] = 2.27; p = .04) and positive margins (HR = 2.32; p = .03).

Conclusion: Male sex and positive margins were negative prognostic factors. Endoscopic resection did not show an increased risk of death compared with more extensive surgical approaches. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1737-E1745, 2016.

Keywords: endoscopic surgery; mucosal melanoma; prognosis; sinonasal tract; survival.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Melanoma / diagnosis*
  • Melanoma / therapy
  • Middle Aged
  • Nasal Mucosa / pathology*
  • Neoplasm Staging
  • Nose Neoplasms / diagnosis*
  • Nose Neoplasms / therapy
  • Paranasal Sinuses / pathology*
  • Prognosis
  • Retrospective Studies
  • Young Adult