Aloe vera and Vitis vinifera improve wound healing in an in vivo rat burn wound model

Mol Med Rep. 2016 Feb;13(2):1070-6. doi: 10.3892/mmr.2015.4681. Epub 2015 Dec 11.


Aloe vera and Vitis vinifera have been traditionally used as wound healing agents. The present study aimed to investigate the effects of aloe emodin and resveratrol in the burn wound healing procedure. Burn wounds are common in developed and developing countries, however, in developing countries, the incidence of severe complications is higher and financial resources are limited. The results of the present study demonstrated that neither aloe emodin or resveratrol were cytotoxic to THP-1 macrophages at concentrations of 1, 100 and 500 ng/ml. A significant increase in wound-healing activity was observed in mice treated with the aloe emodin and resveratrol, compared with those which received control treatments. The levels of IL-1β in the exudates of the burn wound area of the treated mice increased in a time-dependent manner over 7 days following burn wound injury. At 10 days post-injury, steady and progressive wound healing was observed in the control animals. The present study confirmed that increased wound healing occurs following treatment with aloe emodin,, compared with resveratrol, providing support for the use of Aloe vera plants to improve burn wound healing.

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Anthraquinones / chemistry
  • Anthraquinones / pharmacology
  • Anthraquinones / therapeutic use
  • Burns / drug therapy*
  • Burns / pathology
  • Cell Line
  • Cell Proliferation / drug effects
  • Cytokines / metabolism
  • Disease Models, Animal
  • Humans
  • Interleukin-1beta / metabolism
  • Male
  • Mice, Inbred BALB C
  • Resveratrol
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use
  • Vascular Endothelial Growth Factor A / metabolism
  • Vitis / chemistry*
  • Wound Healing* / drug effects


  • Anthraquinones
  • Cytokines
  • Interleukin-1beta
  • Stilbenes
  • Vascular Endothelial Growth Factor A
  • aloe emodin
  • Resveratrol