Abstract
Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.
Keywords:
Naegleria fowleri; miltefosine; primary amebic meningoencephalitis.
Published by Oxford University Press for the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
MeSH terms
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Antiprotozoal Agents / adverse effects*
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Antiprotozoal Agents / therapeutic use*
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Central Nervous System Protozoal Infections / diagnostic imaging
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Central Nervous System Protozoal Infections / drug therapy*
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Central Nervous System Protozoal Infections / mortality
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Central Nervous System Protozoal Infections / parasitology*
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Child
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Fatal Outcome
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Humans
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Male
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Naegleria fowleri* / drug effects
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Naegleria fowleri* / isolation & purification
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Phosphorylcholine / adverse effects
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Phosphorylcholine / analogs & derivatives*
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Phosphorylcholine / therapeutic use
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Treatment Outcome
Substances
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Antiprotozoal Agents
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Phosphorylcholine
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miltefosine