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Case Reports
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Fatal Myocarditis Associated With HHV-6 Following Immunosuppression in Two Children

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Case Reports

Fatal Myocarditis Associated With HHV-6 Following Immunosuppression in Two Children

Heather E Stefanski et al. Pediatrics.

Abstract

Fatal myocarditis is a rare complication in immunosuppressed children. Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. HHV-6 can reactivate during periods of immunosuppression. Here, we report 2 cases in which children were immunosuppressed, one for treatment of Evans syndrome and the other post hematopoietic stem cell transplantation, who developed rapid and fatal HHV-6-associated myocarditis. These cases suggest that HHV-6 infection should be considered as an etiology of myocarditis in immunosuppressed patients regardless of correlating blood levels. Early treatment of HHV-6 in patients with myocarditis could improve morbidity and mortality.

Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
HHV-6-A detection in cardiac tissue in 2 cases (A and B, respectively). Immunofluorescence was performed with ant-HHV-6A gp82/105 antibody. Images captured by confocal microscopy at ×400 magnification and ×1000 magnification (inset). Prominent epicardial tissue staining is evident in both cases.

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