The successful treatment of refractory respiratory failure due to miliary tuberculosis: survival after prolonged extracorporeal membrane oxygenation support

Clin Respir J. 2016 May;10(3):393-9. doi: 10.1111/crj.12437. Epub 2016 Jan 24.

Abstract

Acute respiratory distress syndrome (ARDS) has high morbidity and mortality. Although uncommon, pulmonary tuberculosis (TB) can cause ARDS in patients with extensive pulmonary parenchymal involvement. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an accepted alternative option in refractory hypoxemic respiratory failure. It may normalize gas exchange and allow lung rest, avoiding ventilator induced lung injury. We report the case of a 44-year-old woman who developed ARDS secondary to pulmonary TB. Despite anti-TB treatment and mechanical ventilation, patient had persistent refractory hypoxemia. In order to prevent further lung injury, VV-ECMO support was performed for 73 days. Although the patient experienced several complications, patient was successfully managed on VV-ECMO. VV-ECMO support, in combination with anti-TB drugs, is a useful tool in the treatment of ARDS with refractory hypoxemia caused by miliary TB.

Keywords: extracorporeal membrane oxygenation; miliary; respiratory insufficiency; tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Critical Care
  • Extracorporeal Membrane Oxygenation / methods*
  • Female
  • Humans
  • Respiratory Distress Syndrome / microbiology
  • Respiratory Distress Syndrome / therapy*
  • Treatment Outcome
  • Tuberculosis, Miliary / complications*