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. 2016 Oct;22(11):1452-1462.
doi: 10.1177/1352458515621624. Epub 2015 Dec 18.

Children of Chronically Ill Parents: Relationship Between Parental Multiple Sclerosis and Childhood Developmental Health

Free PMC article

Children of Chronically Ill Parents: Relationship Between Parental Multiple Sclerosis and Childhood Developmental Health

Neda Razaz et al. Mult Scler. .
Free PMC article


Background: Exposure to parental chronic illness is associated with adverse developmental outcomes.

Objective: We examined the association between parental multiple sclerosis (MS) and parental MS-related clinical factors on developmental health.

Methods: We conducted a population-based cohort study in British Columbia, Canada, using linked health databases. The outcome was childhood development at 5 years of age, expressed as vulnerability on the Early Development Instrument (EDI). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.

Results: MS-affected parents (n = 783) were older, more likely to be English speakers, and had higher rates of mental health morbidity (39.6% vs 22.2%, p < 0.001) than unaffected parents (n = 2988). In the adjusted models, children of mothers with MS (aOR = 0.62, 95% CI = 0.44-0.87), but not children of the fathers with MS, had a lower risk of vulnerability on the social development domain of the EDI. However, mental health comorbidity (aOR = 1.62, 95% CI = 1.05-2.50) and physical comorbidity (aOR = 1.67, 95% CI = 1.05-2.64) among mothers with MS were associated with increased vulnerability on the EDI.

Conclusion: Maternal MS, but not paternal MS, was associated with lower rates of developmental vulnerability on the social development domain. However, mental and physical comorbidity among MS-affected mothers were associated with increased developmental vulnerability in children.

Keywords: Multiple sclerosis; anxiety; child development; cohort studies; depression.

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.


Figure 1.
Figure 1.
Schematic depiction of the cohort selection.
Figure 2.
Figure 2.
Rates of children’s vulnerability (%) within each Early Development Instrument (EDI) domain by parental multiple sclerosis (MS) status, British Columbia, Canada. Error bars represent 95% confidence intervals.

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    1. Barkmann C, Romer G, Watson M, et al. Parental physical illness as a risk for psychosocial maladjustment in children and adolescents: Epidemiological findings from a national survey in Germany. Psychosomatics 2007; 48: 476–481. - PubMed
    1. Sieh DS, Meijer AM, Oort FJ, et al. Problem behavior in children of chronically ill parents: A meta-analysis. Clin Child Fam Psychol Rev 2010; 13: 384–397. - PMC - PubMed
    1. Sieh DS, Visser-Meily JM, Meijer AM. Differential outcomes of adolescents with chronically ill and healthy parents. J Child Fam Stud 2013; 22: 209–218. - PMC - PubMed
    1. De Judicibus MA, McCabe MP. The impact of parental multiple sclerosis on the adjustment of children and adolescents. Adolescence 2004; 39: 551–569. - PubMed
    1. Razaz N, Nourian R, Marrie RA, et al. Children’s and adolescents adjustment to parental multiple sclerosis: A systematic review. BMC Neurol 2014; 14: 107. - PMC - PubMed

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