Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease

Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H455-65. doi: 10.1152/ajpheart.00726.2015. Epub 2015 Dec 18.


Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. Notably, adult stem and progenitor cells including mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have progressed into clinical trials and have shown positive benefits. In this review, we overview the major classes of stem and progenitor cells, including pluripotent stem cells, and summarize the state of the art in applying these cell types for treating myocardial infarction and peripheral arterial disease.

Keywords: angiogenesis; hindlimb ischemia; myocardial infarction; peripheral arterial disease; pluripotent stem cell; stem cell therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Ischemia / therapy*
  • Myocardial Ischemia / therapy*
  • Neovascularization, Physiologic*
  • Stem Cell Transplantation / methods*