Introduction: Xantogranulomatous pyelonephritis (XGPN) is a rare chronic inflammatory disease of the kidney that can be focal or diffuse with the focal form imitating greatly renal cell carcinoma (RCC).
Presentation of case: We report a challenging clinical case of a 38-year old male with right flank pain persisting for 3-months, imaging showed an 8cm heterogenous mass of the upper pole of the right kidney and invading the liver. A right radical nephrectomy including the adrenal in the resection was performed under the tentative diagnosis of renal cell carcinoma (RCC) whereas histology revealed focal XGPN.
Discussion: Preoperative diagnosis of focal XGPN was difficult because of radiological similarities to RCC and lack of history of stone disease or urinary tract infection.
Conclusion: This case highlights the need to include XGPN in the differential diagnosis of RCC even in the era of modern imaging.
Keywords: Diagnostic imaging; Infection; Renal cell carcinoma; Tumor; Xantogranulomatous pyelonaphritis.
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