Salivary acinic cell carcinoma: reappraisal and update

Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3511-3531. doi: 10.1007/s00405-015-3855-7. Epub 2015 Dec 19.


Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

Keywords: Acinic cell carcinoma; Mammary analog secretory carcinoma; Pathology; Prognosis; Salivary glands; Therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma, Acinar Cell* / epidemiology
  • Carcinoma, Acinar Cell* / metabolism
  • Carcinoma, Acinar Cell* / pathology
  • Carcinoma, Acinar Cell* / therapy
  • Diagnosis, Differential
  • Disease Models, Animal
  • Humans
  • Microscopy, Electron
  • Parotid Gland
  • Preoperative Care
  • Prognosis
  • Salivary Gland Neoplasms / epidemiology
  • Salivary Gland Neoplasms / metabolism
  • Salivary Gland Neoplasms / pathology
  • Salivary Gland Neoplasms / therapy
  • Salivary Glands, Minor