Regenerating a kidney in a lymph node

Pediatr Nephrol. 2016 Oct;31(10):1553-60. doi: 10.1007/s00467-015-3296-y. Epub 2015 Dec 21.


The ultimate treatment for end-stage renal disease (ESRD) is orthotopic transplantation. However, the demand for kidney transplantation far exceeds the number of available donor organs. While more than 100,000 Americans need a kidney, only 17,000 people receive a kidney transplant each year (National Kidney Foundation's estimations). In recent years, several regenerative medicine/tissue engineering approaches have been exploited to alleviate the kidney shortage crisis. Although these approaches have yielded promising results in experimental animal models, the kidney is a complex organ and translation into the clinical realm has been challenging to date. In this review, we will discuss cell therapy-based approaches for kidney regeneration and whole-kidney tissue engineering strategies, including our innovative approach to regenerate a functional kidney using the lymph node as an in vivo bioreactor.

Keywords: Cell-based regeneration; Kidney; Lymph node; Organogenesis; Whole-organ engineering.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Kidney / growth & development*
  • Kidney Diseases / therapy
  • Lymph Nodes / growth & development
  • Lymph Nodes / physiology*
  • Organogenesis
  • Regeneration / physiology*
  • Regenerative Medicine / methods*
  • Regenerative Medicine / trends
  • Tissue Engineering
  • Tissue Scaffolds