Roles for mismatch repair family proteins in promoting meiotic crossing over

DNA Repair (Amst). 2016 Feb;38:84-93. doi: 10.1016/j.dnarep.2015.11.024. Epub 2015 Dec 2.


The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the asymmetric cleavage of double Holliday junctions (dHJ) to form crossovers. This review discusses how meiotic roles for Msh4-Msh5 and Mlh1-Mlh3 do not fit paradigms established for post-replicative MMR. We also outline models used to explain how these factors promote the formation of meiotic crossovers required for the accurate segregation of chromosome homologs during the Meiosis I division.

Keywords: Crossing over; Holliday junction resolution; Meiosis; Mlh1-Mlh3; Msh4-Msh5.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Crossing Over, Genetic*
  • DNA Mismatch Repair*
  • DNA, Cruciform / metabolism
  • Humans
  • Meiosis*
  • Models, Biological
  • Multiprotein Complexes / metabolism*


  • DNA, Cruciform
  • Multiprotein Complexes