Acridine-based complex as amino acid anion fluorescent sensor in aqueous solution

Spectrochim Acta A Mol Biomol Spectrosc. 2016 Mar 15;157:1-5. doi: 10.1016/j.saa.2015.12.007. Epub 2015 Dec 8.


Novel acridine-based fluorescence sensors containing alaninol ligands, L1 and D1, were designed and synthesized. The structure of the compound was characterized by IR, (1)H NMR, (13)C NMR, MS spectra. L1 and D1 possess efficient Cu(2+) cation ON-OFF selective signaling behavior based on ligand-to-metal binding mechanism at physiological pH condition. Additionally, the L1-Cu(II) and D1-Cu(II) complexes could further serve as reversible OFF-ON signaling sensing ensemble to allow ratiometric response to amino acid anion in aqueous solution.

Keywords: Acridine; Amino acid anion; Cu(2+) cation; Fluorescence sensor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridines / chemistry*
  • Amino Acids / analysis*
  • Anions / analysis
  • Copper / chemistry
  • Fluorescent Dyes / chemistry*
  • Ligands
  • Models, Molecular
  • Propanolamines / chemistry*
  • Spectrometry, Fluorescence / methods


  • Acridines
  • Amino Acids
  • Anions
  • Fluorescent Dyes
  • Ligands
  • Propanolamines
  • 2-aminopropanol
  • Copper