The State of the Orbitofrontal Cortex

Melissa J Sharpe; Andrew M Wikenheiser; Yael Niv; Geoffrey Schoenbaum

doi:10.1016/j.neuron.2015.12.004

The State of the Orbitofrontal Cortex

Neuron. 2015 Dec 16;88(6):1075-1077. doi: 10.1016/j.neuron.2015.12.004.

Authors

Melissa J Sharpe¹, Andrew M Wikenheiser², Yael Niv³, Geoffrey Schoenbaum⁴

Affiliations

¹ National Institute on Drug Abuse, Baltimore, MD 21224, USA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. Electronic address: melissa.sharpe@nih.gov.
² National Institute on Drug Abuse, Baltimore, MD 21224, USA.
³ Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Psychology, Princeton University, Princeton, NJ 08544, USA.
⁴ National Institute on Drug Abuse, Baltimore, MD 21224, USA; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Solomon H. Snyder Department of Neuroscience, The John Hopkins University, Baltimore, MD 21218, USA. Electronic address: geoffrey.schoenbaum@nih.gov.

Abstract

State representation is fundamental to behavior. However, identifying the true state of the world is challenging when explicit cues are ambiguous. Here, Bradfield and colleagues show that the medial OFC is critical for using associative information to discriminate ambiguous states.

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MeSH terms

Animals
Choice Behavior / physiology*
Male
Prefrontal Cortex / physiology*
Psychomotor Performance / physiology*
Reward*

Abstract

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MeSH terms

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