Nifty Alleles, a Plethora of Interactions, and Imagination Advance Understanding of Smc5/6's Roles with Chromosomes

Mol Cell. 2015 Dec 17;60(6):832-3. doi: 10.1016/j.molcel.2015.12.006.


The Smc5/6 complex is involved in DNA replication and repair, but why it is essential is less clear. In this issue of Molecular Cell, Menolfi et al. (2015) use cell cycle-specific alleles to link the essential function of Smc5/6 to resolving replication problems that persist into G2.

Publication types

  • Comment

MeSH terms

  • Cell Cycle Proteins / metabolism*
  • DNA Replication*
  • DNA, Fungal / metabolism*
  • Genes, Essential*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Cell Cycle Proteins
  • DNA, Fungal
  • Saccharomyces cerevisiae Proteins