Characterisation and surface-profiling techniques for composite particles produced by dry powder coating in pharmaceutical drug delivery

Drug Discov Today. 2016 Apr;21(4):550-61. doi: 10.1016/j.drudis.2015.11.013. Epub 2015 Dec 9.

Abstract

The production of composite particles using dry powder coating is a one-step, environmentally friendly, process for the fabrication of particles with targeted properties and favourable functionalities. Diverse functionalities, such flowability enhancement, content uniformity, and dissolution, can be developed from dry particle coating. In this review, we discuss the particle functionalities that can be tailored and the selection of characterisation techniques relevant to understanding their molecular basis. We address key features in the powder blend sampling process and explore the relevant characterisation techniques, focussing on the functionality delivered by dry coating and on surface profiling that explores the dynamics and surface characteristics of the composite blends.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Drug Compounding*
  • Drug Delivery Systems
  • Powders / chemistry*
  • Surface Properties

Substances

  • Powders