Effect of Anodal and Cathodal Transcranial Direct Current Stimulation on DLPFC on Modulation of Inhibitory Control in ADHD

J Atten Disord. 2019 Feb;23(4):325-332. doi: 10.1177/1087054715618792. Epub 2015 Dec 20.

Abstract

Objective: The purpose of this study was to improve the inhibitory control functions through transcranial direct current stimulation (tDCS) in adolescents with ADHD symptoms.

Method: Twenty high school students with ADHD symptoms participated in this single-blinded, crossover, sham-controlled study. All the participants were tested during the application of Stroop and Go/No-Go tasks that is used to measure inhibitory control, using 1.5 mA of tDCS for 15 min over the left dorsolateral prefrontal cortex (DLPFC).

Results: Anodal stimulation on left DLPFC had no effect on interference inhibition during the Stroop task and increased the proportion of correct responses in the "Go stage" of the Go/No-Go test compared with sham condition. Cathodal stimulation on the left DLPFC increased the inhibition accuracy in the inhibition stage during Go/No-Go task in comparison with sham.

Conclusion: tDCS over the left DLPFC of adolescents who suffer from ADHD symptoms can improve inhibitory control in prepotent response inhibition.

Keywords: ADHD impairment; attention deficit and hyperactivity disorder; inhibitory control; transcranial direct current stimulation (tDCS).

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Analysis of Variance
  • Attention Deficit Disorder with Hyperactivity / psychology
  • Attention Deficit Disorder with Hyperactivity / therapy*
  • Cross-Over Studies
  • Humans
  • Inhibition, Psychological*
  • Prefrontal Cortex / physiology
  • Stroop Test
  • Transcranial Direct Current Stimulation / methods*