Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China

Viruses. 2015 Dec 7;7(12):6400-11. doi: 10.3390/v7122947.


Hand, foot, and mouth disease (HFMD), which has led to millions of attacks and several outbreaks across the world and become more predominant in Asia-Pacific Region, especially in Mainland China, is caused by several Human Enteroviruses including new enterovirus, coxsakievirus and echovirus. In recent years, much research has focused on the epidemiological characteristics of HFMD. In this article, multiple characteristics of HFMD such as basic epidemiology, etiology and molecular epidemiology; influencing factors; detection; and surveillance are reviewed, as these can be help protect high risks groups, prevalence prediction and policy making for disease prevention.

Keywords: HFMD; enterovirus; epidemiology; etiology; influencing factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • China / epidemiology
  • Enterovirus / classification*
  • Enterovirus / genetics
  • Enterovirus / isolation & purification
  • Epidemiological Monitoring*
  • Female
  • Hand, Foot and Mouth Disease / diagnosis
  • Hand, Foot and Mouth Disease / epidemiology*
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Incidence
  • Male
  • Molecular Epidemiology
  • Prevalence
  • Seasons