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Review
. 2015 Dec 10;7(12):10417-26.
doi: 10.3390/nu7125541.

The Overlap Between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Clinical Dilemma

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Free PMC article
Review

The Overlap Between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Clinical Dilemma

Archita Makharia et al. Nutrients. .
Free PMC article

Abstract

The spectrum of gluten-related disorders has widened in recent times and includes celiac disease, non-celiac gluten sensitivity, and wheat allergy. The complex of symptoms associated with these diseases, such as diarrhea, constipation or abdominal pain may overlap for the gluten related diseases, and furthermore they can be similar to those caused by various other intestinal diseases, such as irritable bowel syndrome (IBS). The mechanisms underlying symptom generation are diverse for all these diseases. Some patients with celiac disease may remain asymptomatic or have only mild gastrointestinal symptoms and thus may qualify for the diagnosis of IBS in the general clinical practice. Similarly, the overlap of symptoms between IBS and non-celiac gluten sensitivity (NCGS) often creates a dilemma for clinicians. While the treatment of NCGS is exclusion of gluten from the diet, some, but not all, of the patients with IBS also improve on a gluten-free diet. Both IBS and NCGS are common in the general population and both can coexist with each other independently without necessarily sharing a common pathophysiological basis. Although the pathogenesis of NCGS is not well understood, it is likely to be heterogeneous with possible contributing factors such as low-grade intestinal inflammation, increased intestinal barrier function and changes in the intestinal microbiota. Innate immunity may also play a pivotal role. One possible inducer of innate immune response has recently been reported to be amylase-trypsin inhibitor, a protein present in wheat endosperm and the source of flour, along with the gluten proteins.

Keywords: celiac disease; gluten-related disorders; intestine; pathogenesis; wheat allergy.

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References

    1. Chey W.D., Kurlander E.S. Irritable bowel syndrome: A clinical review. JAMA. 2015;313:949–958. doi: 10.1001/jama.2015.0954. - DOI - PubMed
    1. Quigley E.M., Abdel-Hamid H., Barbara G., Bhatia S.J., Boeckxstaens G., de Giorgio R., Delvaux M., Drossman D.A., Foxx-Orenstein A.E., Guarner F., et al. A global perspective on irritable bowel syndrome: A consensus statement of the World Gastroenterology Organisation Summit Task Force on irritable bowel syndrome. J. Clin. Gastroenterol. 2012;46:356–366. doi: 10.1097/MCG.0b013e318247157c. - DOI - PubMed
    1. Chang L., Lembo A., Sultan S. American Gastroenterological Association Institute Technical Review on the pharmacological management of irritable bowel syndrome. Gastroenterology. 2014;147:1149–1172. doi: 10.1053/j.gastro.2014.09.002. - DOI - PubMed
    1. Lovell R.M., Ford A.C. Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clin. Gastroenterol. Hepatol. 2012;10:712–721. doi: 10.1016/j.cgh.2012.02.029. - DOI - PubMed
    1. Chang F.Y., Lu C.L., Chen T.S. The current prevalence of irritable bowel syndrome in Asia. J. Neurogastroenterol. Motil. 2010;16:389–400. doi: 10.5056/jnm.2010.16.4.389. - DOI - PMC - PubMed

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