Chronic non-specific diarrhea of infancy successfully treated with trimethoprim-sulfamethoxazole

Scand J Gastroenterol. 1989 Jun;24(5):589-92. doi: 10.3109/00365528909093094.


Fifteen children who fulfilled the criteria of chronic non-specific diarrhea of infancy were evaluated for intestinal bacterial overgrowth. In 10 of 11 successfully investigated children we found bacterial overgrowth of the small intestine by upper respiratory tract microflora. In 9 of 10 children (group I) treated with trimethoprim-sulfamethoxazole the diarrhea ceased immediately, whereas in all children in group II (n = 5; 3 children excluded because of growth of Yersinia enterocolitica) treated with low-lactose diet the diarrhea persisted (p = 0.004). The results indicate that bacterial overgrowth of the small intestine by upper respiratory tract microflora may be a cause of chronic non-specific diarrhea and that this diarrhea may be successfully treated with trimethoprim-sulfamethoxazole.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / isolation & purification
  • Chronic Disease
  • Clinical Trials as Topic
  • Diarrhea, Infantile / drug therapy*
  • Diarrhea, Infantile / microbiology
  • Drug Combinations / therapeutic use
  • Female
  • Humans
  • Infant
  • Intestine, Small / microbiology
  • Male
  • Prospective Studies
  • Random Allocation
  • Respiratory System / microbiology
  • Sulfamethoxazole / therapeutic use*
  • Trimethoprim / therapeutic use*
  • Trimethoprim, Sulfamethoxazole Drug Combination


  • Anti-Bacterial Agents
  • Drug Combinations
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole