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, 22 (1), 105-8

Effectiveness of Ring Vaccination as Control Strategy for Ebola Virus Disease

Effectiveness of Ring Vaccination as Control Strategy for Ebola Virus Disease

Adam J Kucharski et al. Emerg Infect Dis.

Abstract

Using an Ebola virus disease transmission model, we found that addition of ring vaccination at the outset of the West Africa epidemic might not have led to containment of this disease. However, in later stages of the epidemic or in outbreaks with less intense transmission or more effective control, this strategy could help eliminate the disease.

Keywords: EVD; Ebola virus; Ebola virus disease; Guinea; West Africa; mathematical model; ring vaccination; transmission chains; vaccination; viruses.

Figures

Figure 1
Figure 1
Outbreak dynamics in a model of transmission of Ebola virus disease. A) Chains of transmission generated in a simulated outbreak starting with 2 infected persons on March 1, 2014. Black circles indicate the index case within each cluster, and arrows indicate routes of transmission. Within each cluster, we assumed that there was a 15% probability that a secondary case would be missed and would instead seed a new cluster (these missed links are not shown). B) New cases per week, by date of symptom onset, for the chains of transmission shown in panel A. Colors of clusters in panel A match colors of bars in panel B. C) Observed weekly confirmed and probable cases reported in Conakry Prefecture, Guinea, during March–September 2014. Data were obtained from the Guinea Ministry of Health and World Health Organization Situation Reports (11).
Figure 2
Figure 2
Effectiveness of vaccination strategies for Ebola virus disease under different transmission scenarios. A) Proportion of simulations that led to a large outbreak (defined as >500 clusters) in the early 2014 Guinea transmission scenario. Red lines indicate no vaccination, green lines indicate ring vaccination, blue lines indicate mass vaccination; solid lines indicate outbreaks that started with 1 index case, and dashed lines indicate outbreaks that started with 5 index cases. We simulated 1,000 outbreaks and calculated the proportion that resulted in >500 clusters. When the space between the red and green lines is large, the model suggests that ring vaccination would provide substantial additional value over standard public health control measures alone. B) Proportion of simulations that led to a large outbreak in partial control scenario.

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